Actually I've no problem with Isaac starting if he feels good enough, except the fact that this lineup has no experience playing together. But it's an option, giving Wendell inconstency.
My main issue is how we manage rotations later. The same Isaac, or probably Franz, should go out early to be back with the second unit (playing Cole more with starters to avoid his hero ball?). No lineup should be made by reserves only, and I believe even better if at least two starters are always in. Having depth is good on regular season, but in playoffs you don't play 10/11 guys. Also, Moe and Ingles together are a big big defensive hole, so if the choice is play both, please stagger their minutes.